Effect of 1% ornidazole and 0.25% chlorhexidine gluconate (ornigreatTM gel) in the treatment of chronic periodontitis: a clinical evaluation

  • S.P Gautami
  • M Anudeep
  • P Arunbhupathi
  • G Ramyateja

Abstract

Objectives: To evaluate the efficacy of sub-gingivally delivered combination of 1% Ornidazole and 0.25% chlorhexidine gluconate gel in the treatment of chronic periodontitis.

Design: A split mouth randomized controlled clinical trial

Subjects: 25 patients diagnosed with moderate to severe periodontitis.

Interventions: The selected patients underwent non-surgical periodontal therapy i.e., scaling and root planing and the sites with probing depth ≥5mm were randomly divided into any of the two parallel treatment arms according to split mouth design by flip of a coin.

Group A: Scaling and Root planing followed by placement of Ornigreat gel and

Group B: Scaling and Root planing alone.

Periodontal examination at baseline and at 4 weeks after non-surgical periodontal therapy included the assessment of Plaque index (Loe and Silness for plaque index), Gingival index (Silness and Loe for gingival index), Probing depth and Clinical attachment level.

Results: Intergroup comparison of plaque index at baseline and 4 weeks revealed the p value 0.88 for test sites and control sites which was statistically non-significant.

Intergroup comparison of gingival index at baseline and 4 weeks revealed the p value 0.05 for test sites and control sites which was statistically non-significant

Probing depths at baseline and 4 weeks during intergroup comparison revealed the p-value < 0.05 for test sites and control sites which was statistically significant.

Conclusion: Within the limitations of the study, it can be concluded that the local application of combination of 1% ornidazole and 0.25% chlorhexidine (Ornigreat) gel as an adjunct to SRP reduces the periodontal inflammation compared to Phase-I therapy alone.

Published
2018-10-16
Section
Articles

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eISSN: 0012-835X