Cryptosporidium oocysts in Ghanaian AIDS patients with diarrhoea

  • A Adjei Department of Pathology
  • M Lartey Lecturer, Department of Medicine
  • TK Adiku Consultant, Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra
  • O Rodrigues Consultant, Department of Child Health, Korle-Bu Teaching Hospital, Korle-Bu, Accra
  • L Renner Consultant, Department of Child Health, Korle-Bu Teaching Hospital, Korle-Bu, Accra
  • E Sifah Specialist, Department of Child Health, Korle-Bu Teaching Hospital, Korle-Bu, Accra, Ghana
  • JD Mensah Principal Medical Officer, Korle- Bu Polyclinic, Korle-Bu, Accra, Ghana
  • BD Akanmori Asociate Professor
  • J Otchere Principal Medical Technician
  • BK Bentum Research Assistant
  • KM Bosompem Senior Research Fellow, Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana

Abstract

Background: Although Cryptosporidium spp. infections in acquired immunodeficiency syndrome patients (AIDS) with chronic diarrhoea have been reported in several African countries, there is no information regarding cryptosporidial diarrhoea in Ghanaian AIDS patients.

Objective: To investigate the occurrence of C. parvum and other gastrointestinal parasitic agents in Ghanaian AIDS patients with chronic diarrhoea.

Design: Prospective study of HIV/AIDS patients with diarrhoea over a nine month period.

Setting: Korle-Bu Teaching Hospital and Korle-Bu Polyclinic Accra, Ghana.

Results: Analysis of stool specimens from clinically diagnosed HIV/AIDS (n=2I; mean CD4 count was 288 cells per microliter, 95% confidence interval of 237 to 340 cells per microliter) and HIV-seronegative (n=27) patients revealed C. parvum in six (28.6%) of HIV/AIDS and 10 (37.0%) of the HIV-seronegative patients, respectively. Three other HIV/AIDS cases had other infections involving Strongyloides stercoralis 4.8% (l/21) and Salmonella spp. 9.5% (2/21). There was no concomitant association between C. parvum and any other parasites found. Also, no enterobacteria was found in the HIV-seronegative patients.

Conclusion: This study demonstrates the prevalence of Cryptosporidium sp. in both HIV/ AIDS and HIV-seronegative individuals in Ghana. However, there was no statistical association between cryptosporidiosis and HIV/AIDS (p>0.05).

East African Medical Journal Vol.80(7) 2003: 369-372

Author Biography

KM Bosompem, Senior Research Fellow, Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana
Dr. K.M. Bosompem, Noguchi Memorial Institute for Medical Research, P.O. Box LG581, Legon, Accra, Ghana
Published
2004-05-07
Section
Articles

Journal Identifiers


eISSN: 0012-835X