Study of serum copper and ceruloplasmin levels in Egyptian autistic children

  • Farida El-Baz
  • Mohamed E. Mowafy
  • Ahmed Lotfy
Keywords: Autism, Copper, Ceruloplasmin, Stereotypic movements

Abstract

Background: Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology.

Objective: To assess serum copper and ceruloplasmin levels in Egyptian autistic children patients.

Subjects and methods: 40 participants have been subjected to thorough history taking, complete clinical examination, IQ assessment, estimation of serum copper and ceruloplasmin levels.

Results: A statistically significant difference was found between patients and controls as regards stereotypic movements, absent eye contact, delayed motor development, delayed speech and IQ (p < 0.01 for each item). Mean level of copper was significantly higher in patients than in controls (P < 0.001), also mean level of ceruloplasmin was significantly higher in patients than controls (P = 0.009).

Conclusion: Serum copper level may have a role in the pathogenesis of autism.

Keywords: Autism, Copper, Ceruloplasmin, Stereotypic movements

Published
2018-04-18
Section
Articles

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eISSN: 1110-8630