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Egyptian Journal of Medical Human Genetics

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Colchicine resistant FMF is not always true resistance

TYA Ghaffar, SM Elsayed

Abstract


Crohn’s disease and familial Mediterranean fever are both inflammatory diseases characterized by similar clinical manifestations. The concurrence of the two diseases may pose a challenge to diagnosis and treatment. In this report, we present a child with familial Mediterranean fever and undiagnosed Crohn’s disease which made him apparently resistant to colchicine therapy.
Symptoms of Crohn’s disease were masked by the resistant fever of FMF. Amelioration of symptoms of both diseases was achieved when treatment of both diseases were gradually introduced. Searching of IBD in children with colchicines resistant FMF is mandatory, as both diseases have similar symptoms and responsible genes may modify one another.



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