Ethiopian Pharmaceutical Journal

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Short Communication: Improved Stability and Efficacy of Diclofenac Diethylamine In an Oleogel Based Formulation

B Rajkapoor, DC Goupale


An oleogel-based formulation of diclofenac diethylamine (DFDA) was prepared and evaluated for enhanced stability and efficacy. Efficacy was evaluated by carrageenan-induced paw oedema method on albino rats and compared with marketed emulgels. The present findings revealed that the developed oleogel formulation of DFDA is more stable and effective than the marketed product. Enhanced efficacy of the formulation is probably due to its increased sustainability and penetrability into the skin in oleogel base.
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