Adverse reaction of coartem (artemether-lumefantrine) resulting in oculogyric crisis: a case report

Abstract

An oculogyric crisis is an acute dystonic reaction of the ocular muscles characterized by bilateral dystonic elevation of visual gaze lasting from seconds to hours. This reaction is most explained as an adverse reaction to drugs such as antimalarials, antiemetics, antipsychotics, antidepressants, and antiepileptics. It is important to recognize these ocular symptoms of adverse reaction to medications because, without a thorough patient history, symptoms can be confused with other diseases. Differential diagnoses can include aversive seizures, paroxysmal tonic upward gaze, and encephalopathy. In this paper, we report a case of oculogyric crisis induced by Artemether-lumefantrine( Antimalarial).