Serum urea and creatinine levels in Nigerian human malaria patients

  • EC Onyeneke Department of Biochemistry, University of Benin, Benin-City, Nigeria
  • AM Oghenejode Department of Biochemistry, University of Benin, Benin-City, Nigeria
  • EO Alumanah Department of Biochemistry, University of Nigeria, Nsukka
  • CJ Okonkwo Department of Human Biochemistry, College of Health Science, Nnamdi Azikiwe University, Nnewi Campus
  • NA Okpogba Department of Human Biochemistry, College of Health Science, Nnamdi Azikiwe University, Nnewi Campus
Keywords: Malaria, Serum urea and creatinine, Nigeria

Abstract

Serum urea and creatinine levels were determined in malaria patients infected with P. falciparum. Serum urea levels decreased significantly (P<0.05) in both mild (4.10 ±1.10 mmol/L) and moderate (4.40 ±1.40 mmol/L) parasitaemia when compared to control subjects (5.50 ±1.40 mmol/L). On the other hand, serum creatinine levels decreased in mild parasitaemia (82.00 ±16.87 μmol/L) but increased significantly in moderate (94.30 ± 24.14 μmol/L) and severe parasitaemia (113.90 ± 46.30μmol/L; P<0.05. Control; 88.30 ± 11.87 μmol/L). The relationship of the results to protein metabolism and kidney function is discussed.

KEY WORDS: Malaria, Serum urea and creatinine, Nigeria

Global Jnl Medical Sciences Vol.2(2) 2003: 103-106
Published
2004-05-21
Section
Articles

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eISSN: 1596-2911