Some physical properties of theophylline monohydrate Sustained Release Tablets formulated with Abelmoschus esculentus Gum as a Hydrophilic Matrix

  • GC Onunkwo Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
  • OK Udeala Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Keywords: Sustained release, Abelmoschus esculentus, Hydrophilic matrix

Abstract

Abelmoschus esculentus (okro) gum remarkably prolonged/delayed the release of theophylline monohydrate from the sustained release tablets. It performed better than ethyl cellulose and much better than gelatin as a sustained release drug matrix. It is very effective at low concentrations. The kinetics of drug release changed from first order to Higuchi diffusion controlled as the polymer concentrations increased from 2-10% w/w.

KEY WORDS: Sustained release, Abelmoschus esculentus, Hydrophilic matrix

Global Jnl Medical Sciences Vol.2(2) 2003: 145-152
Published
2004-05-21
Section
Articles

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eISSN: 1596-2911