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Some physical properties of theophylline monohydrate Sustained Release Tablets formulated with <i>Abelmoschus esculentus</i> Gum as a Hydrophilic Matrix

GC Onunkwo
OK Udeala


Abelmoschus esculentus (okro) gum remarkably prolonged/delayed the release of theophylline monohydrate from the sustained release tablets. It performed better than ethyl cellulose and much better than gelatin as a sustained release drug matrix. It is very effective at low concentrations. The kinetics of drug release changed from first order to Higuchi diffusion controlled as the polymer concentrations increased from 2-10% w/w.

KEY WORDS: Sustained release, Abelmoschus esculentus, Hydrophilic matrix

Global Jnl Medical Sciences Vol.2(2) 2003: 145-152

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eISSN: 1596-2911