Composition of statins produced by indigenous strain of Aspergillus terreus

Abstract

Composition of statins produced by Aspergillus terreus 20 indigenous strain in submerged fermentation (SmF) has been studied. Identification of statin compounds in fungal extracts by LC-MS-MS analysis revealed 6 polyketide metabolites: lovastatin (LV) in lactone, acid and methyl ester forms, pravastatin (PV), monacolin L (ML) and simvastatin (SV). For the first time it has been revealed the ability producing simvastatin by A. terreus by direct fermentation.

Keywords: Aspergillus terreus, statins, composition, HPLC, LC-MS-MS analysis, mass spectra

International Journal of Engineering, Science and Technology Vol. 6, No. 1, 2014, pp. 71-76