Study of antioxidant enzymes, lipid peroxidation, lipid profile and Immunologic factor in coronary artery disease in East Azarbijan

Abstract

Background: The oxidative stress and inflammation are cooperative events involved in atherosclerosis development. Aim: In the present study, we assessed the association of MDA, antioxidant markers, high sensitive Creactive protein (hs-CRP) and lipid status parameters in the patients with coronary artery disease (CAD). Significant risk factors such as cigarette and diabetes were excluded from the study. Materials and Methods: Oxidative stress parameters for example malondialdehyde (MDA), antioxidant markers including: erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPX), and total antioxidant capacity (TAC). The inflammation marker and serum lipid status parameters were measured in 120 subjects including 60 CAD patients with angiographically diagnosed CAD and 60 CAD-free subjects as a control group, also diabetics, smoking patients, patients with malignancy, renal and liver disease, and other disease were excluded from the study. Results: The serum MDA and hs-CRP levels were increased significantly as compared to controls. However, erythrocyte SOD, GPX activities and TAC level were reduced significantly in patients (P‹0.05 in all cases). The levels of total cholesterol, Triglyceride, LDL-C were significantly higher and that of HDL-C was meaningfully lower than those of control (P<0.05 in all cases). Conclusions: The association between oxidative stress parameters, antioxidant markers, the inflammation index and lipid status parameters suggest their involvement in atherosclerosis development that may lead to CAD progression.

Keywords: Antioxidant, lipid profile, lipid peroxidation, coronary artery disease