Comparative Study of the Protective Effect of Granulated Sugar and Garri Meal on Petroleum-induced Changes of Lipid Profiles in Albino Rats (Rattusnorvegicus)

Abstract

Crude oil contaminated diet has been reported to induced changes in lipid profile of rats. In this study, 60 albino rats in 6 groups were fed with crude oil contaminated sugar-garri diets at varied concentrations to monitor petroleum-induce lipid profile changes using standard methods. The lipid profiles estimated were total cholesterols, triglycerides, high density lipoprotein cholesterol and Low density lipoproteincholesterol.The data showed that, the levels of total cholesterol (Mmol/l) increased from 2.89+0.08 in sugar fed rats compared with 3.05+0.12 in Gari fed rats. The concentration of triglycerides(Mmol/l) reduced from 1.10+0.51 in sugar fed rats to 1.06 + 0.03 in Gari fed rats while the high density lipoprotein cholesterol(Mmol/l) concentration of 2. 01+0.08 was significantly higher than 1.89 + 0.03 in Gari fed rats (P<0.05).There was no significant difference in Low density lipoprotein cholesterol (Mmol/l) concentrations of 0.68+0.11 in sugar fed rats compared with 0.83 + 0.10 in Gari fed rats. The effect of pre-treatment of the diet with sugar reduced petroleum-induce changes in lipid profile than gari during the exposure of the albino rats to the petroleum diet suggesting that sugarcould possibly ameliorate petroleum-induce changes in lipid profile as shown by the significantlowering of the cholesterol and Low density lipoprotein cholesterol than gari in albino rats. 

Keywords: lipid, Petroleum, Sugar, Gari, Cassava, Changes