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Some biochemical parameters as risk factors in the aetiology of renal disease.


L U Ezeanyika
C E Ugwe
B C Nwanguma

Abstract



An investigation was conducted on the serum levels of some biochemical parameters: glucose, creatinine, urea, cholesterol, uric acid, protein and the electrolytes, sodium, chloride and bicarbonate; as risk factors in the aetiology of renal disease. A total of 121 apparently healthy subjects living in South Eastern Nigeria (average age = 41yrs) were used for the study. For virtually all the parameters tested, the result from some individuals fell outside the reference ranges, but the mean serum levels of all the parameters tested fell within the normal ranges. The result from the Principal Component Analysis (PCA) identified serum glucose, chloride and sodium ions, which accounted for 60.13%, 16.62% and 9.21%, respectively, as the main contributors to renal risk in the population tested. The results from a questionnaire administered to the subjects showed that most of the subjects had a good knowledge of the causes of diabetes, hypertension and renal failure.

Keywords: Glucose, Electrolytes, Renal disease

Journal of Biomedical Investigation Vol. 3 (2) 2005: pp. 5-11
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eISSN: 1597-0043