Article Sidebar
Article Details
Issue
Section
Articles
Material submitted for publication in the Journal of Endocrinology, Metabolism and Diabetes of South Africa (JEMDSA) is accepted provided it has not been published elsewhere. JEMDSA reserves copyright of the material published. Neither JEMDSA nor the Publisher may be held responsible for statements made by the authors.
Main Article Content
Tumour-induced osteomalacia: a curable condition
Abstract
Osteomalacia is a condition characterised by failure of bone
mineralisation. While abnormalities of vitamin D supply, metabolism
or action are the most common and well-known causes, chronic phosphate deficiency, due to either insufficient input (intake or absorption) or renal losses are also important causes of rickets or osteomalacia. Hypophosphataemia also commonly co-exists with vitamin D deficiency, pursuant to secondary hyperparathyroidism. Other causes include chronic calcium deficiency, hypophosphatasia, fluoride and aluminium excess.
In respect of chronic hypophosphataemia-associated rickets/osteomalacia, the commonest aetiology is X-linked dominant hypophosphataemia, XLH, (1:20000 births). Others include Fanconi syndrome, autosomal dominant hypophosphataemic rickets (ADHR) and tumour-induced osteomalacia (TIO).
mineralisation. While abnormalities of vitamin D supply, metabolism
or action are the most common and well-known causes, chronic phosphate deficiency, due to either insufficient input (intake or absorption) or renal losses are also important causes of rickets or osteomalacia. Hypophosphataemia also commonly co-exists with vitamin D deficiency, pursuant to secondary hyperparathyroidism. Other causes include chronic calcium deficiency, hypophosphatasia, fluoride and aluminium excess.
In respect of chronic hypophosphataemia-associated rickets/osteomalacia, the commonest aetiology is X-linked dominant hypophosphataemia, XLH, (1:20000 births). Others include Fanconi syndrome, autosomal dominant hypophosphataemic rickets (ADHR) and tumour-induced osteomalacia (TIO).
