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Clinical characteristics and determinants of invasive mechanical ventilation outcome in adult intensive care unit in Northern Ethiopia: A resource-limited setting


Ephrem Berhe
Tesfay Gebregzabher Gebrehiwet
Hale Teka
Kibrom Gebreselasie Gebrehiwot
Hiluf Ebuy Abraha
Mengistu Hagazi Tequare

Abstract

Objectives: Mechanical ventilation (MV) is a primary modality of supporting organ function in patients who are treated in intensive care  units (ICUs). Although it is lifesaving, it is also associated with life-threatening complications. This study aims to address the existing  paucity of evidence on clinical characteristics and determinants of invasive MV outcomes in adult ICU in North Ethiopia.


Materials and Methods: The study was conducted in the adult ICU of Ayder Comprehensive Specialized Hospital. A hospital-based  prospective study was conducted to collect data using the purposive sampling technique to include all the patients who received invasive  MV from January 2017 to October 2017. Data were analyzed using SPSS version 23.


Results: MV was utilized in 36.7% (n = 105) of critically ill patients admitted to the ICU. The two most common indications for invasive MV  use were hypoxic respiratory failure 44.8% (n = 47) and coma 35.2% (n = 37). The mortality rate among patients who received invasive MV  was 28.6%. Age above 60 years and development of septic shock after intubation were significant determinants of invasive MV-related  mortality.


Conclusion: A significant number of patients admitted to the ICU require respiratory support with invasive MV. Old age and the  development of septic shock after intubation were significant determinants of mortality for patients under invasive MV.


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eISSN: 2694-4561