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Journal of Pharmacy & Bioresources

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A comparative study of the flow enhancing properties of bentonite, magnesium stearate, talc and microcrystalline cellulose

SO Eraga, JO Erebor, MA Iwuagwu

Abstract


A comparative study of granule flow enhancing property of bentonite, magnesium stearate, talc and microcrystalline cellulose (MCC) was undertaken. Bentonite was processed into fine powder. A 10 %w/w of starch granules was prepared and separated into different sizes (˂180, 180-500, 500-710 and 710-850 μm). Each granule size was divided into four parts. The four parts were treated with four different glidants (bentonite, magnesium stearate, talc and MCC) at different concentrations (0, 0.5, 1, 1.5 and 2 %w/w). The resulting granules were subjected to the following analyses: bulk and tapped densities, Hausner’s ratio, angle of repose and flow through an orifice. Results show that all the glidants were comparable at each of the concentrations and granule sizes, except at 710-850 μm granule size with magnesium stearate exhibiting superior flow properties to talc, followed by MCC and lastly bentonite, in that order. Bentonite powder was comparable as a glidant to magnesium stearate, talc and microcrystalline cellulose in the concentrations used in this study except at granule size of 710-850 μm. It can therefore be recommended as a suitable glidant in granule formulations where particle size is below 710 μm.  

Keywords: Bentonite; Flow property; Glidant; Lubricant




http://dx.doi.org/10.4314/jpb.v12i1.3
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