Hypoglycaemic activity of Telfairia occidentalis in rats

  • Olorunfemi A Eseyin Department of Pharmaceutical and Medicinal Chemistry
  • Arnold C Igboasoiyi Department of Pharmaceutical and Medicinal Chemistry
  • Emmanuel Oforah Department of Clinical Pharmacy and Biopharmceutics
  • Nkaima Nkop Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo. Akwa Abom State. Nigeria
  • Akeem Agboke Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo. Akwa Abom State. Nigeria

Abstract

The hypoglycaemic activity of the ethanolic extract of leaf of Telfairia occidentalis was evaluated in normoglycaemic and alloxan–induced diabetic rats. This activity was compared with that of glibenclamide and that of a mixture of glibenclamide and extract. Blood glucose was measured by a glucometer. The extract produced significant reduction in blood glucose level at 2 hrs in normoglycaemic rats, and at 2 and 4hrs in diabetic rats after a single oral dose of 250mg/kg. The reduction in blood glucose level produced by the sub-acute administration of extract on the 5th, 10th and 15th day were comparable to that of glibenclamide.These results suggest that the leaves of Telfairia occidentalis possess hypoglycemic activity in normoglycemic and alloxan-induced diabetic rats and this could be beneficial in the ethnotherapy of diabetes mellitus.

Key words: Telfairia occidentalis; Glibenclamide; Hypoglycaemic activity; Alloxan-induced diabetes. Journal of Pharmacy and Bioresources Vol. 2 (1) 2005: 36-42
Published
2005-10-12
Section
Articles

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