(+) Aeroplysinin-1: antibacterial and cytotoxic principle from the sponge Pseudoceratina (Aiolocroia) crassa

  • MES Koker
Keywords: Bioactivity-guided isolation, ( ) Aeroplysinin-1, Antibacterial, Cytotoxic

Abstract

Bioactivity- guided fractionation of methylene chloride, ethyl acetate fractions of the sponge Pseudoceratina (Aiolocroia) crassa has led to the isolation and characterisation of (+)-aeroplysinin-1 as the bioactive principle. The structure of the compound was determined by spectroscopic methods.  (+)-Aeroplysinin-1 showed broad spectrum activity against a number of aerobic bacteria, Gram-positive and Gram-negative anaerobes, L1210, P 388 cells, weakly cytotoxic against KB cells in addition to the reported antibacterial activity.

Keywords: Bioactivity-guided isolation; (+) Aeroplysinin-1, Antibacterial; Cytotoxic

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eISSN: 0189-8442