Effects of some edible oils on renal function in rats

  • KE Imafidon
  • LO Okunrobo
Keywords: Kidney, Creatinine, Urea, Aminotransferases, Histological analysis


This work was done to investigate the effects of palm oil, groundnut oil and coconut oil on kidney function. Biochemical analysis carried out includes the determinations of creatinine, urea, sodium, potassium, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. Measurement of kidney weight, body weight, feed intake, faecal output as well as histological examination were also carried out. Consequently, 32 albino rats were divided into 4 groups of 8 rats each, the control rats were fed rats’ chow only while others were given 90% rats’ chow supplemented with 10% of palm oil, coconut oil or groundnut oil. They were given these diets along with water for six weeks ad libitum. Results showed that body and kidney weight were not significantly altered compared with control. Also urea and sodium levels were not significantly altered although potassium levels were significantly reduced compared with control. Creatinine levels were significantly increased in all the test rats. ALT levels were significantly increased in rats fed groundnut and palm oil based diet while AST levels were significantly increased only in those rats fed coconut oil – based diet. Histological examination shows the presence of chronic inflammatory cells. These results suggest that renal function was compromised when rats were given these oil-based diets.

Keywords: Kidney; Creatinine; Urea; Aminotransferases; Histological analysis


Journal Identifiers

eISSN: 0189-8442