Synthesis, characterization and antibacterial evaluation of palmitoylphenylalanine and palmitoyltryptophan
Abstract
The synthesis, characterization and anti-bacterial evaluation of two palmitoyl amino acids is reported in this work. The reported antimicrobial activity of some fatty acid derivatives encouraged the investigation of the possible influence of an aromatic group substituent on a saturated fatty acid residue. The compounds were synthesized by the condensation of palmitoyl chloride and the respective aromatic amino acid; and they were unequivocally characterized by different spectroscopic techniques. The compounds were tested for possible antibacterial activity against clinical isolate of Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli, and were found to possess no activity against any of the tested organisms.
Keywords: Synthesis; Palmitoylphenylalanine; Palmitoyltryptophan;Antibacterial
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
