Synthesis, characterization and antibacterial evaluation of palmitoylphenylalanine and palmitoyltryptophan

Abstract

The synthesis, characterization and anti-bacterial evaluation of two palmitoyl amino acids is reported in this work. The reported antimicrobial activity of some fatty acid derivatives encouraged the investigation of the possible influence of an aromatic group substituent on a saturated fatty acid residue. The compounds were synthesized by the condensation of palmitoyl chloride and the respective aromatic amino acid; and they were unequivocally characterized by different spectroscopic techniques. The compounds were tested for possible antibacterial activity against clinical isolate of Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli, and were found to possess no activity against any of the tested organisms.

Keywords: Synthesis; Palmitoylphenylalanine; Palmitoyltryptophan;Antibacterial