A Review of Hepatitis C Virus (HCV) and the Current Management of Genotype 1 Chronic HCV Infection

  • IS Wokoma
  • RI Oko-Jaja
Keywords: Hepatitis C genotype 1, Pegylated Interferon (Peg IFN), Protease inhibitors (PI), Telaprevir (TVR), Boceprevir (BOC), Ribavirin(RBV)


Background: Chronic Hepatitis C virus (HCV) is the primary cause of cirrhosis, hepatocellular carcinoma (HCC), and end- stage liver disease. The addition of protease inhibitor with peginterferon alfa and ribavirin (triple therapy) for genotype 1 infected patients, are the current standard of care.

Method: Data was sourced from available journals and internet based search using pubmed, medline and google search.

Results: successful Treatment of Genotype 1 HCV infected patients with protease inhibitor based triple therapy has improved sustained virologic response (SVR) rates and treatment induced clearance of HCV infection.

Conclusion: significant progress in the management of chronic hepatitis C genotype 1 with the introduction of protease inhibitor (PI) in 2011 with peginterferon and ribavirin has optimized sustained virologic response (SVR).

Keywords: Hepatitis C genotype 1; Pegylated Interferon (Peg IFN); Protease inhibitors (PI), Telaprevir (TVR), Boceprevir (BOC), Ribavirin(RBV).


Journal Identifiers

print ISSN: 1597-4292