C-Reactive Protein and Serum Amyloid-A Response to N-butyl Cyanoacrylate-based Sutures in Sahel Goats

Abstract

The use of biomaterials as suture materials triggering less acute phase response to tissue damage for cutanuous wounds closure has  been the goal of numerous researchers. The introduction of Cyanoacrylate into clinical practice is of keen interest which could be an  alternative to conventional suture materials. This study focused on monitoring responses to tissue damage elicited by Cyanoacrylate and  Nylon based suture materials for wound closure. Ten apparently healthy male goats (Bucks) with mean age of 9.7±1.33 months and mean  weight 13.2±1.31 kg were randomly separated into two groups A & B of five (5) bucks each. Incisions made in Group A were closed  using N-butyl Cyanoacrylate while nylon was used in group B. Blood samples were taken before the procedures and after at 0, 5, 8, 24, 48  and 72 h for estimation of serum C-Reactive Protein (CRP) and Serum Amyloid-A (SAA). Results indicated that Nylon based suture material  triggered early and significant tissue damages based on serum CRP elevated levels while serum SAA levels were comparable  when nylon and N-butyl cyanocarylate were used as suture materials for wound closures.