Antidiabetyics / Antihypertensives Prescription Profile In Osuth, Sagamu And Environment
AbstractPurpose of the study: The aims of this paper are to investigate drug utilization in the utilization in the management of diabetes mellitus and hypertension is sagamu, Ogun state and its environment and to evaluate their agreement with established guideline
Methodology: prescription on both diabetes and hypertension were collected over a period of the weeks at the Ogun state University Teaching Hospital and from a general (state) hospital in its environment. Statistical analysis was by using a chi – square test for proportions and students t – test for parametric data. Ap – value of less than 0.05 was considered significant.
Results: the study involved 1360 consecutive prescriptions form the medical unit of the general hospital and 1440 consecutive prescriptions from the Teaching Hospital (712from the diabetic clinic and 728 from the hypertensive clinic). A total of 210 patients (15.4%), 1040 patients (76.5%) and 110 patients (8.1%) in the general hospital were prescribed one or more antidibetic agents, antihypentensive and combination of both respectively. In the teaching hospital a total of 330 patients (22.9%) 633 patients (43.9%) and 477 patients (33.1%) considered respectively to be diabetic alone, hypertensive alone and combined diabetic and hypertensive. In both setting, most 50% of the diabetics were treated with glibenclamide, About 90 (27.3%) of the patient in the general hospital were on two sulfonylurea. Insulin was prescribed top 3 (0.9%) and 16 (2.2%) of the prescribed in both hospitals: even when prescribed, it is in combination with a sulfonylurea.
The use of antihypertensive drugs was more prevalent among patients without diabetes than those with diabetes in both population [general hospital 202 (19.4%) vs 28 (19 .7%) and in the teaching hospital 1239 (20.4%) vs. 27 (4.3) %, p <).0001]. Among the patients without diabetes prescribed most frequently in the general hospital, whereas diuretics 46 (35. 6%),nifedipine 39 (30.2%) and aldomet 25 (15.9%) were prescribed most frequently in the teaching hospital. In the group with diabetes, propanolol 9 (32.1%) and centrally actually acting drugs 9 (32.1%) were used slightly more commonly than diuretics 5 (17. 8%) and calcium channel blockers 5 (17. 8%) in the general hospital. The choice of diuretics was limited in the two hospital setting
Conclusions; The prescription pattern of antidiabetice and more importantly antihypertensive is still at variance with established guidelines in these hospitals
Key Words: prescription profile, Antidiadetics Antithypertesives
Nigerian Journal of Clinical Practice Vol.7(1) 2004: 15-20