Changes in Serum Proteins and Creatinine levels in HIV Infected Nigerians

  • RA Audu Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
  • AS Akanmu College of Medicine, University of Lagos, P.M.B. 12003 Idi-Araba, Lagos, Nigeria.
  • AG Mafe Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
  • C Efienemokwu Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
  • AZ Musa Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
  • E Lemoha Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
  • MI Odunaike Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
  • EO Funso-Adebayo Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
  • E Meshack Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
  • EO Idigbe Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
Keywords: Serum proteins, Creatinine, Albumin, Globulin, HIV

Abstract

Immune dysregulation in terms of hypergammaglobulinaemia and hypogammaglobulinaemia was part of definition of immunodeficiency that characterized AIDS. This results in either raised level of total plasma/serum protein or low level of plasma/serum protein depending on which component of immune dysregulation predominates. This study examined the level of total serum proteins and globulins in HIV infected Nigerians. 64 patients with HIV infection and 10 apparently healthy subjects were recruited from 3 hospitals in Lagos Metropolis. They were examined for the presence of TB and malaria. Serum total protein, albumin and creatinine levels were determined using commercially available kits while the globulin level was computed. Level of immunodeficiency was also determined by CD4+ cell count, using the FACS count method. Data obtained from the patients were compared with values obtained from 10 healthy controls; using appropriate statistical tests on EPI-INFO V 6.0. Results showed that hypergammaglobulinaemia is the major immune dysregulation found with globulin level of 7.4g/d1 as compared with 2.9g/d1 in healthy control though it was not statistically significant. Total serum protein was also higher in HIV infected patients than the controls. The serum globulin was found to correlate negatively with CD4 cell count (r = -0.28, P = 0.0067). Serum creatinine appears not to differ significantly between control and infected patients although the creatinine levels has a positive correlation to plasma globulin levels (r = 0.45, p = 0.001). In conclusion hypergammaglobulinaemia was found to be common in HIV infected Nigerians. This was associated with raised level of plasma creatinine.

KEY WORDS: Serum proteins, Creatinine, Albumin, Globulin and HIV

Nigerian Journal of Health and Biomedical Sciences Vol.3(2) 2004: 69-72

Author Biography

RA Audu, Nigerian Institute of Medical Research, P.M.B. 2013, Yaba
Correspondence to: R. A. Audu Human Virology Laboratory, Nigerian Institute of Medical Research, P.M.B. 2013, Yaba, Lagos. Tel: 234-1-4801716. Fax: 234-1-3425171
Published
2004-09-21
Section
Articles

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eISSN: 1595-8272