Nigerian Journal of Medicine

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Effect of low intensity continuous training programme on serum uric acid in the non pharmacological management of hypertension: a randomized controlled trial

S Lamina, C.G Okoye


Elevated serum uric acid (SUA) is considered to be positively associated with cardiovascular event risk factor in hypertension. Also, the positive role of exercise in the management of Hypertension has been well and long established. However the relationship between SUA level and hypertensive management particularly in non pharmacological technique is ambiguous and unclear. Therefore the purpose of the present study was to determine the effect of continuous low intensity training programme on SUA level and cardiovascular parameters in male subjects with hypertension. Twohundred and seventeen male patients with mild to moderate (systolic blood pressure [SBP] between 140-180 & diastolic blood pressure [DBP] between 90-109 mmHg) essential hypertension were age matched and grouped into continuous and control groups. The continuous (n=112; 58.63 ± 7.22years) group involved in an 8 weeks interval training (35-9% HR max reserve) programme of between 45minutes to 60 minutes, while agematched controls hypertensive (n=105; 58.27± 6.24 years) group remain sedentary during this period. Cardiovascular parameters (SBP, DBP & VO2max) and SUA were assessed. Students't and Pearson correlation tests were used in data analysis. Findings of the study revealed significant effect of interval training programme on VO2 max, SBP, and DBP and SUA concentration at p< 0.05 and changes in VO2max negatively correlated with SUA (r= -.266) at p<0.05. it was concluded that low intensity continuous training programme is an effective nonpharmacological management and may prevent cardiovascular event through the down regulation of SUA in hypertension.
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