Anti Coagulation And Antithrombotic Effects Of <i>Triclisia Dictyophylla</i>

Abstract

Triclisia Dictyophylla (moonseed) root was investigated for the anticoagulation and antithrombotic properties. The median lethal dose (LD50) based on
Lorke\'s methods was 550mg/kg. The aqueous root extract of T. dictyophylla prolonged the in-vitro whole human blood clotting time at concentrations of 50mg/2ml and 100mg/2ml of whole blood and at a concentration of 200mg/2ml of whole blood, complete anticoagulation effect was achieved. The prothrombin time of the different concentrations was unattainable even after 48hours. At a concentration of 200mg/2ml of semi clotted whole blood (invitro),
the clot was dislodged. The roots extract of T. dictyophylla has in-vitro anticoagulation and antithrombotic properties, perhaps justifying its use in the treatment of edematous pain.

Keywords: Triclisia Dictyophylla, Menispermaceae, human blood, coagulation, Fibrinolysis, antithrombosis

Nigerian Journal of Natural Products and Medicine Vol. 11 2007 pp. 29-31