ANTI-ULCER ACTIVITY OF STEM BARK OF DANIELLIA OLIVERI

  • DN Onwukaeme Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Plateau State, Nigeria.
  • F Udoh Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Plateau State, Nigeria.
Keywords: Daniellia oliveri, rats, guinea pigs, stem bark, anti-ulcer, anti-cholinergic

Abstract

The MeOH extract of Daniellia oliveri showed a dose related activity on the induced ulcers. The 500mg/kg extract had an activity (P<0.05) compared with vehicle. The reference drug, cimedtidine, used in the test at 100mg/kg did not show any activity in the ASA-induced ulcers. The effect of the extract on acetylcholine (Ach) induced contraction on rat duodenum was also assessed. Like the reference antagonist, atropine, used in the test, the extract showed a non-competitive antagonism on the induced contraction. This anti-spasmodic effect of the extract could partly explain the anti-ulcer effect. This is the first report on the anti-ulcer activities of the methanolic extract of D. oliveri stem bark.

Key Words: Daniellia oliveri, rats, guinea pigs, stem bark, anti-ulcer, anti-cholinergic

Nig. J. Nat Prod. And Med. Vol.3 1999: 39-41
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