Effects of extracellular zinc ion on the rate of oxygen consumption of rat brain mitochondria

  • B.I Kukoyi
Keywords: brain mitochondria, oxygen consumption.

Abstract

The inhibitory effect of extracellular zinc ion on the rate of oxygen consumption of rat brain mitochondria pre-incubated in 1.0 mM Ca2+EDTA were determined. There was a significant increase [P<0.01] in the rate of oxygen consumption in the rat brain mitochondria pre-incubated in 1.0 mM
Ca2+EDTA in a succinate initiated reaction. The reverse was the case when the concentration of Ca2+EDTA was increased to 10 mM. A 20μM zinc-aspartate was found to have no inhibitory effect on the rate of oxygen consumption of the brain mitochondria pre-incubated with 1.0 mM Ca2+EDTA when compared with the control that lacked 1.0 mM Ca2+EDTA, however there was a significant decrease [P<0.01] in the rate of oxygen consumption of the rat brain mitochondria in the control experiment.

Key Words: Zinc, brain mitochondria, oxygen consumption.

Section
Articles

Journal Identifiers


eISSN: 0794-859X