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Nigerian Journal of Physiological Sciences

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Anti-nociceptive and anti-inflammatory properties of the ethanolic extract of Lagenaria breviflora whole fruit in rat and mice

SA Onasanwo, AB Saba, OA Oridupa, AA Oyagbemi, BV Owoyele

Abstract


The present study was conducted to evaluate the anti-nociceptive and anti-inflammatory properties of an ethanol extract of whole fruit of Lagenaria breviflora (LB) in rat and mice. Analgesic activity was measured by hot plate, formalin-induced paw licking, and acetic acid-induced abdominal writhing tests, while anti-inflammatory activity was determined by inhibition of carrageenan-induced paw oedema. Extract-treated animals exhibited significantly (P<0.05) higher pain threshold, lower number of licking of paws in response to formalin-induced irritation and writhing movements in response to acetic acid-induced writhing movement. There was significant (P<0.05) inhibition of carrageenan-induced paw oedema in rats pre-treated with the extract (50, 100, 200mg/kg) by 6.4%, 27.5%, 55.9% respectively. Analgesic effect of the extract (50, 100, 200mg/kg) in hot plate test was observable within 30 minutes of administration with maximum effect obtainable 90 minutes post-administration. Also, the effect of the extract (50, 100 and 200mg/kg) was dose dependent in both the early (88.17±6.21, 80.33±3.49 and 72.33±5.16) and late (72.50±3.95, 53.83±3.96 and 35.83±3.78) phases of formalin-induced paw licking, and in acetic acid-induced writhing with inhibition of 26.8%, 48.1% and 58.1% respectively. Its effect was comparable especially at 200mg/kg body weight to those of diclofenac, indomethacin and ibuprofen. It could be suggested from the findings of this experiment that the extract may be mediating its action as a central analgesic agent but the peripheral analgesic effect was preponderant based on its outcome from the pain models..

Keywords: Lagenaria breviflora, Whole fruit, Anti-nociceptive, Anti-inflammatory

Nig. J. Physiol. Sci. 26 (June 2011) 071 – 076



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