Factors associated with tuberculosis treatment failure in the Central East Health region of Burkina Faso

  • Adama Diallo
  • Désiré Lucien Dahourou
  • Ter Tiero Elias Dah
  • Souleymane Tassembedo
  • Romial Sawadogo
  • Nicolas Meda
Keywords: Tuberculosis, treatment, failure, Burkina Faso

Abstract

Introduction: Tuberculosis treatment failure results in increased risk of morbidity, drug resistance, transmission and mortality. There are few data about tuberculosis treatment outcomes in Burkina Faso. The current study investigated the factors associated with tuberculosis treatment failure in the central east health region of Burkina Faso.

Methods: We conducted a case-control study. All cases of pulmonary tuberculosis failing first-line treatment matched to those who were cured (controls) in the Central Eastern Region were sampled from January 2010 to December 2014. Predictors of treatment failure were determined using multiple conditional logistic regression.

Results: A total of 381 patients with positive microscopic pulmonary tuberculosis were included. Of these 76 cases failed first-line treatment while 305 controls were cured. Weight loss between diagnosis and first sputum-smear examination was significantly associated with the tuberculosis treatment failure [aOR: 2.5, 95% CI: 1.3-4.7]. In addition, the delay from between treatment initiation to first sputum-smear examination, and high bacillary load at the first sputum-smear examination were significantly associated with treatment failure (p<0.001).

Conclusion: Strengthening the relationship between health care services and local communities to improve the follow-up of tuberculosis patients, and improving adherence to tuberculosis treatment among tuberculosis patients with weight loss between treatment initiation and 2-month sputum-smear examination could be useful to reduce the risk of unsuccessful outcome.

Keywords: Tuberculosis, treatment, failure, Burkina Faso

Author Biographies

Adama Diallo
National Tuberculosis Control Program, Ouagadougou, Burkina Faso
Désiré Lucien Dahourou
Centre Muraz, Department of Clinical Research, Bobo-Dioulasso, Burkina Faso
Ter Tiero Elias Dah
Centre Muraz, Department of Clinical Research, Bobo-Dioulasso, Burkina Faso
Souleymane Tassembedo
Centre Muraz, Department of Clinical Research, Bobo-Dioulasso, Burkina Faso
Romial Sawadogo
Central East Health Regional Direction, Tenkodogo, Burkina Faso
Nicolas Meda
Centre Muraz, Department of Clinical Research, Bobo-Dioulasso, Burkina Faso; University of Ouagadougou, Department of Public Health, Ouagadougou, Burkina Faso
Published
2019-02-11
Section
Articles

Journal Identifiers


eISSN: 1937-8688