Histopathologic characteristics and short-term outcomes of colorectal cancer in young Tunisian patients: one center’s experience

  • Mahdi Bouassida
  • Bilel Feidi
  • Bassem Mroua
  • Mohamed Fadhel Chtourou
  • Selim Sassi
  • Fathi Chebbi
  • Souheil Bouchtili
  • Mohamed Mongi Mighri
  • Hassen Touinsi
  • Mohamed Msaddak Azzouz
  • Sadok Sassi

Abstract

Introduction: Colorectal carcinoma (CRC) is generally a disease of persons older than 40 years. Concerning younger patients, controversies still exist regarding features and prognosis of CRC. We performed this study to characterise CRC in young patients (≤40 years) as well as to evaluate short-term outcome in comparison with older patients (>40 years) with CRC. Methods: Clinical and histopathological parameters of 40 patients aged 40 years or less were compared with 240 patients aged more than 40 years. Results: In young patients, the minority suffered from hereditary cancer syndromes (0.4%). Furthermore, up to 87% of young patients denied any cancers in their families. Compared with older patients, young patients had more mucinous adenocarcinomas (32.5% vs. 11.5%; p=0.02), more venous invasion (p=0.021), more perineural invasion (p=0.028). For grading (p=0.42), lymphatic invasion (p=0.17) and tumor sites (p=0.46), no significant differences between young and older patients were found. Young patients had less post operative morbidity (p=0.039), less post operative mortality (0.029). Young and older patients had the same overall 1-year survival rates (p=0.24), and the same cancer-related 1-year survival rates (p=0.1). Conclusion: Tunisian patients present with colorectal cancer at a more advanced stage of the disease at younger ages compared to developed countries. The early detection of CRC followed by a sufficient oncologic treatment is crucial regardless of age. It is mandatory for all patients with suspicious symptoms to undergo early adequate diagnoses.

Pan African Medical Journal 2012; 12:10

Author Biographies

Mahdi Bouassida

 

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia
Bilel Feidi

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

Bassem Mroua

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

Mohamed Fadhel Chtourou

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

Selim Sassi

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

Fathi Chebbi

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

Souheil Bouchtili

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

Mohamed Mongi Mighri

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

Hassen Touinsi

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

Mohamed Msaddak Azzouz

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

Sadok Sassi

Mohamed Thahar Maamouri Hospital, Nabeul, Tunisia

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Articles

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eISSN: 1937-8688