Hepatitis B-delta: diagnostic and therapeutic aspects at the Yalgado Ouédraogo University Hospital of Ouagadougou (Burkina-Faso)

Abstract

Objective: to study the diagnostic and therapeutic aspects of hepatitis B-delta at the University Hospital Center Yalgado Ouedraogo.
Patients and methods: this was a retrospective study conducted from January 2006 to March 2017 (11 years old). Patients with hepatitis B virus and positive delta serology were included. The quantifi cation of the DNA of the hepatitis B virus was carried out by real-time PCR (Roche CobasTaqMan) with a detection threshold of 10 IU / mL. The quantifi cation of the delta virus RNA was carried out by gene amplifi cation (RT-PCR) with a detection threshold of 100 IU /ml.
Results: A total of 499 patients with hepatitis B virus achieved delta serology, it was positive in 11 patients (2.2%) including 7 men and 4 women. the average age was 42.5 ± 7.9 years with extremes of 30 and 55 years. The viral load B was performed in all patients: it was detectable in 09 patients and undetectable in 03 patients. The quantifi cation of the delta virus RNA was
carried out in 10 patients, it was detectable in 06 patients. Simultaneous replication of B and delta viruses was present in 05 patients (45.4%). Jaundice was the circumstance of discovery in 03 patients. Physical examination was normal in 10 patients. Of the 05 patients treated with tenofovir, 04 had a duration of treatment ≥ 03 years and the complete virological response (HBV) was obtained in all (100%). One patient was treated for 58 weeks against the hepatitis delta virus. When the treatment was stopped, he had a partial virological and biochemical response.
Conclusion: The diffi culties related to the non-availability of diagnostic tests, at their high cost as well as the cost of pegylated interferon constitute a real handicap for the adequate management of this infection.