Association between vitamin A and E and apolipoprotein A and B levels in type 2 diabetes

  • P Yavari Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • F Siassi Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • M Jalali Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • M Chamari Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • A Keshavarz Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • H Layegh Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • M Yavari Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • K Mohammad Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • B Larigani Undersecretary of Research, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Objective. To determine the relationship between serum vitamin A and E and apolipoprotein levels in type 2 diabetic patients.

Setting. Shariati Hospital, Tehran, Iran.

Subjects and methods. One hundred and seventeen eligible type 2 diabetic patients who attended the Endocrine Research and Metabolism Center between 2002 and 2004 were enrolled in the study. Blood samples were collected after a 12 - 14-hour overnight fast for the measurement of serum levels of total cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein (apo) A1 and apoB, and vitamins A and E. Anthropometric indices were determined by physical examination. Data were analysed statistically using Pearson's coefficient, multiple regression, and partial and bivariate correlations.

Results. The mean body mass index (BMI) of the subjects was 27.4 ± 3.7 kg/m2. The mean (± standard deviation (SD)) serum levels of vitamins A and E were 0.5 ± 0.1 μg/ml and 9.5 ± 2.6 μg/ml, respectively. There were no significant differences in the plasma levels of vitamins A and E in males and females. Mean serum levels of vitamins A and E were within the normal range for both sexes. Serum lipid levels (total cholesterol, triglyceride and apoB) correlated with serum levels of vitamin E (p < 0.05). Serum levels of vitamins A and E were also correlated (p < 0.05). Standardised vitamin E levels showed significant negative correlation with most studied lipid profiles (p < 0.05).

Conclusion. This study found that mean serum levels of the natural antioxidants vitamin E, and especially vitamin A, were close to the lower end of the normal range of these antioxidants in type 2 diabetics. Also, serum vitamin E and standardised vitamin E levels were important predictors of serum apoA1 levels in these patients.

South African Journal of Clinical Nutrition Vol. 19(1) 2006: 39-44
Published
2006-08-29
Section
Articles

Journal Identifiers


eISSN: 2078-6204
print ISSN: 2078-6190