Abacavir: its use and hypersensitivity

  • H Rabie
  • KL Henning
  • P Schoeman
  • N de Villiers
  • GHJ Pretorius
  • M Cotton


Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first- and second-line HIV therapy and as a substitute for stavudine and zidovudine when toxicity is a problem. Although it is safe and well tolerated, a  lifethreatening hypersensitivity reaction can occur. The risk for developing this reaction relates to the presence of specific genotypes, especially HLA-B*5701.

Journal Identifiers

eISSN: 2078-6751
print ISSN: 1608-9693