Oestrogen supplementation in gamete intrafallopian transfer (GIFT) — a prospective randomised study

  • APH de Decker Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven, Belgium
  • TF Kruger Reproductive Biology Unit, Stellenbosch University and Tygerberg Hospital, W Cape
  • TI Siebert Reproductive Biology Unit, Stellenbosch University and Tygerberg Hospital, W Cape
  • JP van der Merwe Reproductive Biology Unit, Stellenbosch University and Tygerberg Hospital, W Cape
  • CJ Lombard Division of Epidemiology and Biostatistics, Medical Research Council, Tygerbergt

Abstract

Objective. To investigate the impact of oestrogen supplementation from the early luteal to the late proliferative phase on biochemical and ongoing pregnancy rates in gamete intrafallopian transfer (GIFT).
Methods. Ninety-five patients were assigned to clomiphene citrate-human menopausal gonadotrophin (hMG)-induced GIFT cycles, with or without the use of oestrogen support (oral administration of estradiol valerate). The main outcome measures were biochemical pregnancy rate and clinical pregnancy rate.
Results. The biochemical pregnancy rate was 38.09% in the oestrogen group v. 22.9% in the control group (p = 0.096, 95% CI: 5.7 - 37.3%). The clinical pregnancy rate in the oestrogen supplementation group was 23.8% v. 14.58% in the control group (p = 0.1988, 95% CI: 10.3 - 31.7%).
Conclusion. Although the results of this study show no significant statistical difference, there is a clinical trend in favour of giving oestrogen support.
South African Journal of Obstetrics and Gynaecology Vol.11(1) 2005: 6-8
Published
2005-06-22
Section
Articles

Journal Identifiers


eISSN: 2305-8862
print ISSN: 0038-2329