Oestrogen supplementation in gamete intrafallopian transfer (GIFT) — a prospective randomised study
AbstractObjective. To investigate the impact of oestrogen supplementation from the early luteal to the late proliferative phase on biochemical and ongoing pregnancy rates in gamete intrafallopian transfer (GIFT).
Methods. Ninety-five patients were assigned to clomiphene citrate-human menopausal gonadotrophin (hMG)-induced GIFT cycles, with or without the use of oestrogen support (oral administration of estradiol valerate). The main outcome measures were biochemical pregnancy rate and clinical pregnancy rate.
Results. The biochemical pregnancy rate was 38.09% in the oestrogen group v. 22.9% in the control group (p = 0.096, 95% CI: 5.7 - 37.3%). The clinical pregnancy rate in the oestrogen supplementation group was 23.8% v. 14.58% in the control group (p = 0.1988, 95% CI: 10.3 - 31.7%).
Conclusion. Although the results of this study show no significant statistical difference, there is a clinical trend in favour of giving oestrogen support.
South African Journal of Obstetrics and Gynaecology Vol.11(1) 2005: 6-8