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Oral Pre-anaesthetic Medication with a New Benzodiazepine Hypnotic


SA Hare

Abstract

A new benzodiazepine derivative (Ro 5-4200) was used as a hypnotic in a pilot study on 30 patients the night before an operation. The dosage used was 2 mg (1 tablet). Results proved very encouraging, and it was then decided to conduct a controlled double-blind trial comparing Ro 5-4200, phenobarbital 100 mg and a placebo In 150 patients (50 patients each way). At a dosage of 2 mg Ro 5-4200 produced significantly better results than phenobarbital and the placebo as an oral, sleep-inducing premedication.

S. Afr. Med. J., 47, 109 (1973)

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eISSN: 2078-5135
print ISSN: 0256-9574