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South African Medical Journal

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Lymphoproliferative disorders in non-AIDS associated Kaposi's sarcoma

M.E. Stein, D Spencer, R Dansey, Y Perner, K Gunther, W.R. Bezwoda

Abstract


The association of the non-AIDS-related, classic fonn of Kaposi's sarcoma (KS) with secondary malignancies, especially Iymphoproliferative disorders, has frequently been noted. However, in endemic: African-type KS, such an association has been reported only rarely. A review of 62 non-AIDS-related cases of KS treated and followed up at Johannesburg General Hospital between 1980 and 1992 revealed 8 patients (13%)'in whom KS was associated with malignant Iymphoproliferative disorders. The prevalence of secondary Iymphoproliferative disorders was not significantly different among patients with classic KS (3/15; 20%) when compared with those who had African KS (4/47; 8%). In both forms of KS subtle disturbances of immunity have been described which may play a role in the pathogenesis of secondary Iymphoproliferative disorders, although the factors responsible and the pathogenetic mechanisms involved in malignant lymphoid transfonnation in these patients have not been fully elucidated.




AJOL African Journals Online