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South African Medical Journal

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Iron dextran in the treatment of iron-deficiency anaemia of pregnancy - Haematological response and incidence of side-effects

M.L. Stein, K.D. Gunston, R.M. May

Abstract


Sixty pregnant patients with a haemoglobin (Hb) < 8 g/dl arid proven iron-deficiency anaemia were randomly allocated to two treatment groups. Group A received the usual recommended dose of iron dextran (Imferon; Fisons) and group 8 received two-thirds of the recommended dose. A further 30 patients received oral iron (group C). There was no difference in Hb value between the three groups 4 weeks after treatment or 3 months after delivery. At 6 months after delivery, a higher mean Hb value was found in the patients in group A than those in groups 8 and C. Significantly higher serum ferritin levels were found in group A and this difference was still present 6 months postnatally. There was no significant difference in the incidence of delayed reactions between the two groups who received iron dextran.




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