Intradermal vaccination against hepatitis B in a group of medical students

  • N.S. Brink
  • A.B. Murray


A prospective study of a low-dose (one-tenth) intradermal regimen using recombinant hepatitis B vaccine was undertaken during two consecutive years in 4th-year medical students. Eighty one per cent of the vaccinees (123/152) seroconverted with anti-HBs levels of > 10 lU/l. The lower titre of hepatitis B surface antibodies compared with published studies on intramuscular immunisation, together with a seroconversion rate of only 81%, makes the intradermal method, in our opinion, a suboptimal form of hepatitis B immunisation.


Journal Identifiers

eISSN: 0256-95749
print ISSN: 2078-5135