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South African Medical Journal

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Intradermal vaccination against hepatitis B in a group of medical students

N.S. Brink, A.B. Murray

Abstract


A prospective study of a low-dose (one-tenth) intradermal regimen using recombinant hepatitis B vaccine was undertaken during two consecutive years in 4th-year medical students. Eighty one per cent of the vaccinees (123/152) seroconverted with anti-HBs levels of > 10 lU/l. The lower titre of hepatitis B surface antibodies compared with published studies on intramuscular immunisation, together with a seroconversion rate of only 81%, makes the intradermal method, in our opinion, a suboptimal form of hepatitis B immunisation.




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