The role of phosphatidyl-glycerol in the determination of fetal lung maturity
Phosphatidyl-glycerot (PG) and the lecithin/sphingomyelin (LIS) ratio were determined on amniotic fluid from 140 patients to evaluate the role of PG estimation as a functional fetal lung maturity test. PG was absent without associated respiratory distress syndrome (RDS) in 17 cases (12%).and present in 123; 3 of the infants born to these patients developed slight hyaline membrane disease. There were no neonatal deaths. When both PG and the LIS ratio were determined the accuracy of prediction of the RDS improved from 87% to 93%. PG determination should not be used as a substitute for the LIS ratio, butshould be used in conjunction with it in high-risk situations.
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