The use of vincristine in refractory auto-immune thrombocytopenic purpura

  • R van Zyl-Smit
  • P Jacobs

Abstract

Two patients with auto-immune thrombocytopenic purpura are reported who continued to bleed despite high doses of corticosteroids, immunosuppressive therapy and splenectomy. The addition of vincristine to their therapeutic regimen produced a response in each case and both patients are now off all therapy without significant bleeding. It is suggested that this agent may be of value in selected cases where conventional regimens have failed or where splenectomy and corticosteroids are contra-indicated.

S. Afr. Med. J., 48, 2039 (1974).

Author Biographies

R van Zyl-Smit
Department of Haematology, University of Cape Town and Haematology Clinic, Groote Schuur Hospital, Cape Town
P Jacobs
Department of Haematology, University of Cape Town and Haematology Clinic, Groote Schuur Hospital, Cape Town
Published
2018-04-17
Section
Articles

Journal Identifiers


eISSN: 0256-95749
print ISSN: 2078-5135