The use of vincristine in refractory auto-immune thrombocytopenic purpura
AbstractTwo patients with auto-immune thrombocytopenic purpura are reported who continued to bleed despite high doses of corticosteroids, immunosuppressive therapy and splenectomy. The addition of vincristine to their therapeutic regimen produced a response in each case and both patients are now off all therapy without significant bleeding. It is suggested that this agent may be of value in selected cases where conventional regimens have failed or where splenectomy and corticosteroids are contra-indicated.
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