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South African Medical Journal

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Human cells in culture: Revislted

J. Op't Hof

Abstract


Human cells in vitro offer considerable advantages in the study and  detection of defects in human chromosomes and gene products. Of all the  euploid cells of the mammalian organism the fibroblasts are capable of  reflecting many different metabolic disorders. These methods, combined with recently developed techniques for the early detection of genetic  disorders allow the assessment of a 'high risk' pregnancy. Cell hybridization has become of paramount importance to genetic analysis and has proved  very useful in assigning gene information to certain chromosomes



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