Frequency of methicillin resistance among Staphylococcus aureus clinical isolates in Khartoum State, Sudan
Background: Methicillin-resistant Staphylococcus aureus (MRSA) have emerged as an important cause of nosocomial and community-acquired infections ranging from mild to severe life-threatening infections. Therefore, a reliable detection of such strains is required for effective treatment.
Objectives: To determine the frequency and the antibiogram of MRSA among different clinical isolates.
Study Design: A cross-sectional, descriptive study.
Materials and Methods: Standard bacteriological methods, disk diffusion and PCR were performed to determine the frequency of MRSA among different clinical isolates.
Results: The overall results showed 96/210 (45.7%) of isolates were MRSA mostly
recovered from wounds and blood stream. High percentage was detected in hospitalassociated (HA) strains (64.2%) rather than community (CA) (37.1%) (P-value < 0.001). From the generated Antibiogram, Co-trimoxazole was the most active (80.2%), while Penicillin was the least one (6.2%).
Conclusion: As MRSA strains were mostly isolated from Hospitals, clinicians should be aware of such burden strains. Local frequency investigation of MRSA is recommended for perfect diagnosis and treatment.
Keywords: MRSA, S. aureus, mecA, Sudan
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