Risk factors for mortality among tuberculosis patients on treatment at Bugando Medical Centre in north-western Tanzania: a retrospective cross-sectional study

  • Daniel W. Gunda Weill Bugando School of Medicine
  • Semvua B. Kilonzo Weill Bugando School of Medicine
  • Salum M. Bulegesi Weill Bugando School of Medicine
  • Bonaventura C.T. Mpondo university of Dodoma, Dodoma Tanzania
  • Elichilia R. Shao Kilimanjaro Christian Medical University College, Moshi
Keywords: Tuberculosis, treatment, mortality, old age, anaemia, Tanzania

Abstract

 

Background: Tuberculosis (TB) is still an important cause of morbidity and mortality worldwide. Though it can effectively be treated, still a significant proportion of patients die on the course of their treatment. The objective of this study was to determine the outcome and risk factors of mortality among patients diagnosed with TB in a tertiary hospital in north-western Tanzania.Methods: A retrospective cross sectional study was done among all patients diagnosed with TB between January and December 2015 at Bugando Medical Centre. Information of demographic characteristics, smear positivity, haemoglobin concentration, HIV status, CD4 counts for HIV positive patients and treatment outcomes were collected and analysed. TB treatment outcomes as dead or alive were calculated and logistic regression was done to determine the factors associated with increased risk of death of patients on anti-TB treatment.Results: In total 701 patients were diagnosed with TB during the study period. Of these, 361 (51.5%) were males with a median age of 38 (IQR 27- 47) and 421 (60.06%) were younger than 40 years. Majority of the participants 409 (58.35%) had smear positive pulmonary tuberculosis and about half of patients (51.07%) tested positive for HIV. Of the enrolled patients 610 (87.02%) were alive at the end of TB treatment while 91 (12.98%) died in the course of treatment. The odds of deaths of patients on anti-TB treatment were strongly associated with male sex, HIV co infection and severe anaemia.Conclusion: The proportion of patients who die from TB treatment at BMC is high, with an increased risk of death among HIV co-infected, older than 40 years and severely anaemic patients. Improvement of strategies for early diagnosis and prompt treatment of TB patients will potentially improve treatment outcome.

Author Biographies

Daniel W. Gunda, Weill Bugando School of Medicine
internal medicine, lecturer
Semvua B. Kilonzo, Weill Bugando School of Medicine
Department of internal medicine, lecturer
Salum M. Bulegesi, Weill Bugando School of Medicine
Department of internal medicine
Bonaventura C.T. Mpondo, university of Dodoma, Dodoma Tanzania
Department of internal medicine
Elichilia R. Shao, Kilimanjaro Christian Medical University College, Moshi
Department of infectious diseases, intectious diseasses specialist
Published
2016-11-13
How to Cite
GundaD. W., KilonzoS. B., BulegesiS. M., MpondoB. C., & ShaoE. R. (2016). Risk factors for mortality among tuberculosis patients on treatment at Bugando Medical Centre in north-western Tanzania: a retrospective cross-sectional study. Tanzania Journal of Health Research, 18(4). https://doi.org/10.4314/thrb.v18i4.
Section
Articles

Journal Identifiers


eISSN: 1821-9241
print ISSN: 1821-6404