Predictive equations for spirometric reference values in a healthy adult suburban population in Tanzania

  • Toril Morkve Knudsen Centre for International Health, University of Bergen
  • Odd Morkve Centre for International Health, University of Bergen
  • Sayoki Mfinanga Muhimbili Medical Research Centre, National Institute for Medical Research
  • Jon Hardie Institute of Medicine, University of Bergen; Departement of Thoracic Diseases, Haukeland University Hospital
Keywords: Reference values, spirometry, lung function, adults

Abstract

This study was conducted in Kinondoni district, Dar Es Salaam, Tanzania, with the objectives to generate prediction equations for forced expiratory volume in 1 second (FEV1), forced expiratory volume in 6 seconds (FEV6), FEV1/FEV6 ratio and peak expiratory flow (PEF) from a non-symptomatic sample of the population, and to compare these equations to published reference values. The study included adults aged ≥ 15 years who were recruited by use of community based, multistage cluster random sampling. Participants performed spirometry and answered questionnaires regarding respiratory symptoms and socioeconomic conditions. Anthropometric data were collected. Selection of subjects for generation of reference values followed American Thoracic Society (ATS) recommendations. Data were analyzed using multiple regression techniques. Fifty two men and 98 women were selected to the reference value group. FEV1, FEV6, FEV1/FEV6 and PEF were regressed against age, height and weight.. For men a curvilinear model was chosen when predicting FEV1, FEV6 and PEF, and a linear model predicted FEV1/FEV6. For women a linear model was used in the regression equations. The reference values generated from our study were lower than in several previously published studies. Our study suggests that assessment of respiratory function should be based on reference values generated from the same population as those being assessed.

Published
2011-07-09
How to Cite
KnudsenT. M., MorkveO., MfinangaS., & HardieJ. (2011). Predictive equations for spirometric reference values in a healthy adult suburban population in Tanzania. Tanzania Journal of Health Research, 13(3), 214-223. https://doi.org/10.4314/thrb.v13i3.64540
Section
Articles

Journal Identifiers


eISSN: 1821-9241
print ISSN: 1821-6404