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Tropical Journal of Obstetrics and Gynaecology

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Correlations Between Seminal Plasma Hormones and Sperm Biophysical Parameters in Infertile Males in Ibadan

Ayodele O. Arowojolu, Oluyemi Akinloye, Olayiwola B. Shittu, Christopher A. Adejuwon

Abstract


Context: There is a complex relationship between seminal plasma hormone levels and infertility in men. Previous studies had shown no specific pattern in the serum or seminal plasma hormone profiles of men with infertility and it is debatable whether there is a need to perform routine seminal hormone assays in the management of men with infertility.


Objective: The aim of this study is to determine of there is a relationship between seminal plasma hormone levels and semen biophysical parameters in infertile males.


Study Design, Setting and Subjects: Healthy male volunteers, comprising 20 normozoospermics, 20 oligozoospermics and 11 azoospermics were recruited from the Urology and Gynaecology Clinics at the University College Hospital, Ibadan. Semen samples were analysed according to the WHO guidelines and seminal plasma prolactin, follicle-stimulating hormone (FSH), luteinising hormone (LH) and testosterone concentrations were estimated by enzyme immunometric method according to the WHO protocol.


Main Outcome Measures: The correlation between semen biophysical parameters and seminal plasma hormone levels in infertile men.


Results: A significant positive correlation was seen between seminal plasma FSH concentration and seminal plasma volume in all subjects. In normozoospermic men, significant correlation was found only between prolactin concentration and sperm viability and between LH concentration and sperm motility.


However, in oligozoospermic males, prolactin concentration had significant positive correlation with sperm count and motility while LH concentration had significant positive correlation with sperm motility only.


Conclusion:Seminal plasma hormone assays are of no value in assessing male infertility.


Key Words: Semen, Seminal Plasma, Gonadotropins, Infertility.


[Trop J Obstet Gynaecol, 2003, 20: 7-11]



http://dx.doi.org/10.4314/tjog.v20i1.14390
AJOL African Journals Online