PROMOTING ACCESS TO AFRICAN RESEARCH

Tropical Journal of Obstetrics and Gynaecology

Log in or Register to get access to full text downloads.

Remember me or Register



Safety and efficacy of Bolus administration of magnesium sulphate for preeclampsia

NO Enaruna, ME Aziken, ART Cert

Abstract


Context: Magnesium sulphate is currently the drug of choice in the prevention and treatment of eclampsia. On-going research is addressing its administration in terms of dosage, duration and safety.
Objective: We evaluated a modified method of magnesium sulphate administration with respect to safety, efficacy and maternofetal outcome.
Design, Setting And Subjects: This was a prospective cohort study conducted at the UBTH, Benin City with patients managed for severe preeclampsia between June and December, 2011. The Zuspan regimen was compared with a modified intravenous regimen in which magnesium maintenance therapy was given as 1g hourly bolus injection administered over 10 minutes. Both methods were evaluated for safety, efficacy and materno-fetal outcome.
Result: The mean age, parity, gestational age and body mass index were 28.09±5.5 years, 2.72±1.98, 36.67±3.54 weeks and 26.51±5.60 respectively. Both methods achieved therapeutic levels, but blood pressure control was better in the continuous group than the bolus group (27% vs 100%, P=0.000). Birth asphyxia occurred in 14.8% of the babies and was 3 times more in the continuous group (22% vs 7.5%; p=0.062). More babies in the bolus group were admitted to SCBU (54.1% vs 7.9%; p=0.000). There was no early neonatal death, and no maternal death in the first week of puerperium.
Conclusion: This study showed that hourly bolus intravenous administration of magnesium sulphate is comparable to continuous intravenous therapy in terms of safety and efficacy in the treatment of severe preeclampsia. A larger scale study is recommended to further confirm our findings.

Keywords: safety, efficacy, bolus magnesium sulphate, preeclampsia, University of Benin Teaching Hospital

Trop J Obstet Gynaecol, 30 (1), April 2013



AJOL African Journals Online