PROMOTING ACCESS TO AFRICAN RESEARCH

Tropical Journal of Pharmaceutical Research

Log in or Register to get access to full text downloads.

Remember me or Register



Evaluation of the suspending properties of Abizia zygia gum on sulphadimidine suspension

M N Femi-Oyewo, M O Adedokun, T O Olusoga

Abstract




Purpose: Some excipients are currently available for the formulation of pharmaceutical suspensions. The purpose of this study is to search for a cheap and effective natural excipient that can be used as an effective alternative for the formulation of pharmaceutical suspensions.

Method: The suspending properties of Albizia zygia gum (family Mimosoideae) were evaluated comparatively with those of Compound Tragacanth, Acacia and Gelatin at concentration range of 0.5 – 4.0%w/v in Sulphadimidine suspension. Characterization tests were carried out on purified Albizia zygia gum. Sedimentation volume (%), rheology and particle size analysis were employed as evaluation parameters. The values obtained therefrom were used as basis for comparison of the suspending agents studied.

Results: Albizia zygia gum is devoid of alkaloids, anthraquinones and carbohydrates which ensures its “inertness”. Albizia zygia gum (2.5%w/v) produced a comparable suspending ability as 4%w/v Compound Tragacanth. Also, the suspending ability of all the materials was found to be in the order: Albizia zygia > Compound Tragacanth gum > Acacia gum > Gelatin. At all concentrations employed, Albizia zygia gum had the strongest suspending ability relative to the other materials.

Conclusion: The results suggest that, due to the high viscosity of Albizia zygia gum, its mucilage can be a stabilizer of choice when high viscosity is desired. It can also serve as a good thickening agent in both pharmaceutical and food industries.



Keywords: Albizia zygia, suspending agents, sedimentation volume, rheology, particle size

> Tropical Journal of Pharmaceutical Research Vol. 3 (1) 2004: pp. 279-284



http://dx.doi.org/10.4314/tjpr.v3i1.14610
AJOL African Journals Online