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Tropical Journal of Pharmaceutical Research

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Urinary paraquat concentration and white blood cell count as prognostic factors in paraquat poisoning

Qinliang Xu, Xinli Wang, Qiang Wu, Xiangdong Jian, Baotian Kan, Beijun Gao, Ke Wang

Abstract


Purpose: To investigate the effect of white blood cell (WBC) and urinary paraquat (PQ) levels on prognostic factors in patients exposed to PQ intoxication using multivariate logistic regression analysis.
Methods: A total of 104 subjects intoxicated with PQ between December 2015 and July 2016 were used in this retrospective study. They comprised patients who survived (n = 78), and patients who died (n = 26). Clinical features and prognostic parameters were analyzed in both groups. Multivariate logistic regression analysis was used to establish a prognostic correlation model based on results from single factor variables.
Results: Comparison of demographic and clinical attributes between the two groups, survivors (n = 78) and non-survivors (n = 26), revealed that those who survived were not as old (33.3 ± 9.9 years) as nonsurvivors (41.5 ± 12.9 years). In addition, on admission, it was found that the survivors ingested lower amounts of PQ (31.6 ± 13.8 ml) than non-survivors (67.88 ± 31.2 ml). There were significant differences between the two groups with respect to WBC, neutrophils, lymphocytes, lactate dehydrogenase (LDH), creatine kinase (CK), amylase, uric acid (UA), pH, partial pressure of oxygen (PaO2), base excess (BE), lactic acid, and D-dimer levels (p < 0.05).
Conclusion: WBC and urine PQ concentration have strong correlation with prognostic factors in PQ poisoning.

Keywords: Paraquat intoxication, Dithionite test, Multivariate logistic analysis, Prognosis, Predictors




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