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Tropical Journal of Pharmaceutical Research

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Etiologic analysis of Chinese patients with agranulocytosis and hematopathies infected with resistant bacteria: Antibacterial effect of tigecycline

Feifei Che, Chunqian Wan, Xiaodong Wang, Jiao Chen, Juan Huang

Abstract


Purpose: To assess the etiologic characteristics of resistant bacterial infections occurring in agranulocytosis patients with hematopathies, and to determine the effect of tigecycline (TGC).
Methods: After ineffective treatment with carbapenem, all of the patients were divided into the following three groups: TGC alone (15 cases); TGC as initial treatment, followed by a combination with other antibiotics (40 cases); and TGC in combination with other antibiotics from the start of treatment (71 cases).
Results: Among the 126 patients, 108 had fevers (85.71 %). The most common infection site was lung, accounting for 71.43 % of all infections. A total of 52 pathogens were isolated from 126 hospitalized patients, including 38 Gram-negative bacteria (70.37 %), 14 Gram-positive bacteria (25.93 %), and 2 fungi (3.70 %). TGC treatment efficacy was 50.79 %. There were no statistically significant differences between the three treatment groups (p = 0.473). Adverse drug reaction was nausea and vomiting (14.29 %), nausea without vomiting (11.90 %), diarrhea (6.35 %), and generalized skin rash with itching (3.17 %).
Conclusion: TGC is effective in treating neutropenic patients with hematopathies who are infected with resistant bacteria. The side effects of TGC are few; thus, TGC is safe and generally well-tolerated.

Keywords: Tigecycline, Agranulocytosis, Resistant bacteria, Hematopathy, Neutropenic patients




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