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Tropical Journal of Pharmaceutical Research

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Application of statins in management of glioma: Recent advances

Qinyi Xu, Jun Liu, Dong Wang, Yinong Xu, Meng Ji, Junhui Chen, Yuhai Wang

Abstract


Gliomas are common primary intra-cerebral tumors in adults, and seriously threaten the health and life of affected patients, especially highly-malignant gliomas, such as glioblastoma multiforme. The clinical prognosis of glioma patients is poor, even for those who have received comprehensive treatment including surgery and concurrent chemo- and/or radio-therapy. As a structural analog of β-hydroxy-β- methylglutaryl coenzyme A (HMG CoA) reductase, statins are a restrictive enzyme in the metabolism of cholesterol. Recent laboratory studies and clinical trials have demonstrated that statins can exert antitumor effect, improve clinical prognosis and significantly prolong the survival time of glioma patients. This article is aimed to highlight the mechanisms of the anti-glioma effect of statins and review recent advances in the management of the disease.

Keywords: Glioma, Glioblastoma multiforme, Intra-cerebral tumors, Statins, Prognosis, Survival time, β-Hydroxy-β-methylglutaryl coenzyme A (HMG CoA) reductase




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